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Title: Inhibition of N-acetyltransferase activity and DNA-2-aminofluorene adducts by glycyrrhizic acid in human colon tumour cells
Authors: 鍾景光(Jing-Gung Chung);(Huei-Ling Chang);(Wen-Chuan Lin);王煌輝(Hwang-Huei Wang);(Chin-Chung Yeh);(Chi-Fu Hung);(Yuh-Ching Li)
Contributors: 生命科學院生物科技學系;中國附醫醫學研究部
Glycyrrhizic acid (GA) was tested for inhibition of arylamine N-acetyltransferase (NAT) ac- tivity in a human colon tumour (adenocarcinoma) cell line (colo 205). Two assay systems were performed, one with cellular cytosols (9000 g supernatant), the other with intact colon tumour cell cultures. The NAT activity in a human colon tumour cell line was inhibited by GA in a dose-dependent manner in both types of systems examined. The data also indicated that GA decreased the apparent values of Km and Vmax of NAT enzymes from human colon tumour cells in both examined systems. The DNA-2-amino¯uorene adduct formation in human colon tumour cells were inhibited by GA. This report is the ®rst to demonstrate that GA does inhibit human colon tumour cell NAT activity and DNA adduct formation.
Keywords: N-acetyltransferase;glycyrrhizic acid;human colon tumour cells;2-amino¯uorene.
Date: 2000-02
Issue Date: 2009-08-20 18:11:44 (UTC+8)
Relation: FOOD AND CHEMICAL TOXICOLOGY 38(3):163~172
Appears in Collections:[生物科技學系暨碩士班] 期刊論文

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